Search results for " beclomethasone dipropionate"

showing 5 items of 5 documents

Phospholipid-polyaspartamide micelles for pulmonary delivery of corticosteroids

2011

A novel drug delivery system for beclomethasone dipropionate (BDP) has been constructed through self-assembly of a pegylated phospholipid-polyaminoacid conjugate. This copolymer was obtained by chemical reaction of α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethyleneglycol)2000] (DSPE-PEG(2000)-NH(2)). Benefiting from the amphiphilic structure with the hydrophilic shell based on both PHEA and PEG and many hydrophobic stearoyl tails, PHEA-PEG(2000)-DSPE copolymer was able to self assemble into micelles in aqueous media above a concentration of 1.23 × 10(-7)M, determined by fluorescence studies. During the self-assembling …

ErythrocytesBiocompatibilityCell SurvivalDrug CompoundingDrug StorageALPHABETA-Poly(N-2-hydroxyethyl)-dl- aspartamide (PHEA) 12-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethyleneglycol)2000](DSPE-PEG2000-NH2) Polymeric micelles Drug delivery Beclomethasone dipropionate (BDP) Pulmonary diseasesPhospholipidPharmaceutical Science[object Object]HemolysisMicelleCell LinePolyethylene Glycolschemistry.chemical_compoundDrug StabilityAmphiphilePEG ratioPulmonary diseasesHumans?Beclomethasone dipropionate (BDP)Particle SizeLungMicellesDrug CarriersChromatographyAqueous solutionMolecular StructureChemistryPhosphatidylethanolaminesBeclomethasonetechnology industry and agriculture?-Poly(N-2-hydroxyethyl)-dl-aspartamide (PHEA)Spectrometry FluorescenceSolubilitySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoDrug deliveryDrug deliveryPolymeric micellesNanocarriersPeptidesHydrophobic and Hydrophilic InteractionsNuclear chemistry
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65) LUNG LOCALIZATION OF AEROSOLISED BECLOMETHASONE DIPROPIONATE-LOADED NANOPARTICLES AND THEIR POSSIBLE ROLE IN ENHANCING ANTI-INFLAMMATION ACTION O…

2012

Settore CHIM/09 - Farmaceutico Tecnologico ApplicativoPOLYMERIC NANOPARTICLES BECLOMETHASONE DIPROPIONATE
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POLYMERIC MICELLES BASED ON A PHOSPHOLIPID/ POLYASPARTAMIDIC COPOLYMER FOR BECLOMETHASONE DIPROPIONATE DELIVERY TO THE LUNGS

2010

Settore CHIM/09 - Farmaceutico Tecnologico Applicativoalphabeta-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) 12-Distearoyl-sn-glycero-3-Phosphoethanolamine-N-[Amino(Polyethylene glycol)2000] (DSPE-PEG2000-NH2) polymeric micelles drug delivery beclomethasone dipropionate (BDP) pulmonary diseases.
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Polymeric micelles based on a polyaspartamide copolymer for pulmonary delivery of beclomethasone dipropionate

2015

beclomethasone dipropionatepolyaspartamidepulmonary deliveryPolymeric micellesPolymeric micelles; polyaspartamide; pulmonary delivery; beclomethasone dipropionatePolymeric micelles polyaspartamide pulmonary delivery beclomethasone dipropionate
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Realization of polyaspartamide-based nanoparticles and in vivo lung biodistribution evaluation of a loaded gucocorticoid after aerosolization in mice

2016

Abstract In this study, novel polymeric nanoparticles (NPs) were developed and their potential as carriers for beclomethasone dipropionate (BDP) into the lung after aerosolization was demonstrated by in vivo studies in mice. In particular, these NPs were obtained starting from two polyaspartamide-based copolymers which were synthesized by chemical reaction of α,β-poly(N-2-hydroxyethyl)- dl -aspartamide (PHEA) and its pegylated derivative (PHEA-PEG2000) with poly(lactic acid) (PLA). To obtain nanosized particles, the high pressure homogenization (HPH)—solvent evaporation method was followed by using an organic phase containing both PHEA-PLA and PHEA-PEG2000-PLA (at a weight ratio equal to 1:…

polymeric nanoparticles beclomethasone dipropionate aerosolization in miceBiodistributionDrug Evaluation PreclinicalPolymeric nanoparticles Beclomethasone dipropionate (BDP) PolyhydroxyethylaspartamidePharmaceutical ScienceNanotechnology02 engineering and technology010402 general chemistry01 natural scienceschemistry.chemical_compoundMicePulmonary surfactantIn vivoPEG ratioAdministration InhalationmedicineAnimalsTissue DistributionGlucocorticoidsLungAerosolizationAerosolsChromatographyLungmedicine.diagnostic_testtechnology industry and agricultureBeclomethasonerespiratory system021001 nanoscience & nanotechnology0104 chemical sciencesLactic acidBronchoalveolar lavagemedicine.anatomical_structurechemistryNanoparticles0210 nano-technologyPeptidesBronchoalveolar Lavage Fluid
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